A popular and powerful psychedelic, typically used in two ways; either it is vapourised for a short 'breakthrough' experience, or it is taken in combination with an enzyme inhibitor for a long, intense trip (this is also known as ayahuasca or pharmahuasca).
These combinations are considered extremely harmful and should always be avoided.
lithium: There is a large number of reports indicating a high seizure and psychosis risk from this combination.
There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
tramadol: Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
These combinations are not usually physically harmful, but may produce undesirable effects.
amphetamines: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
cannabis: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
cocaine: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences