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    MXE

    Aliases: methoxetamine, 3-meo-2'oxo-pce

    Categories

    dissociative research-chemical habit-forming

    Summary

    A popular dissociative drug which is an analogue of ketamine, though less sedating and more potent by weight, with a subjectively more 'complicated' set of effects.

    ⚠️ AVOID: Alcohol, Benzodiazepines, Opioids, Other CNS depressants, including substances that have an effect on Serotonin (For example, yet not limited to MDMA, Amphetamine, and other stimulants)
    ⚠️ Bodyweight plays a slight factor in MXE dosing, these are values for a 175lb (80kg) male

    Dose Information

    Onset, Duration & After-effects

    • Onset:
      • Insufflated: 5-20 minutes
      • Oral: 30-60 minutes
      • Sublingual: 15-45 minutes
    • Duration: 3-6 hours
    • After-effects: 2-48 hours

    Helpful Links

    Known Combinations

    These combinations are considered extremely harmful and should always be avoided.

    alcohol: There is a high risk of memory loss, vomiting and severe ataxia from this combination.
    ghb/gbl: Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the individual falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
    opioids: This combination can potentiate the effects of the opioid

    There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

    dextromethorphan: There is a risk of serotonin syndrome when combining DXM with MXE, due to DXM and MXE both being SRI’s. MXE and DXM having notable affinities for the serotonin transporter.
    maois: MAO-B inhibitors appear to increase the potency of MXE. MAO-A inhbitors have some negative reports associated with the combination but there isn't much information available

    These combinations are not usually physically harmful, but may produce undesirable effects.

    amphetamines: Risk of tachycardia, hypertension, and manic states
    benzodiazepines: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the affected individual in the recovery position to prevent vomit aspiration from excess.
    cocaine: Stimulants taken with MXE can lead to hypermanic states much more easily, especially if sleep is avoided.
    dox: As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
    mdma: There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues.
    nbomes: As an NMDA antagonist MXE potentiates NBOMes which can be unpleasantly intense
    pcp: There are no reports available about this combination
    ssris: Depending on the SSRI this combination can be unpredictable

    These drugs work together to cause an effect greater than the sum of their parts.

    5-meo-xxt: Little information exists about this combination.

    Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction.

    caffeine: No likely interactions

    Studies