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    Disclaimer
    ☠ This substance has been associated with serious adverse events including fatalities. Use extreme caution.
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25P-NBOMe Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: Nbome-2c-p

    Psychedelic Research-chemical

    Summary dose.wiki TripSit

    Extremely potent compound active in the low hundreds of micrograms range. Small measurement errors can create dangerous multi-fold overdoses. Reports of intense vasoconstriction, tachycardia, hypertension, agitation, and seizures at high doses, with multiple documented fatalities in the NBOMe series.

    Dose Information source varies by route

    ROA Light Common Strong Heavy
    Sublingual 250-450ug 450-700ug 700-1500ug 1500µg+
    Oral 250-450ug 450-700ug 700-1500ug 1500ug+
    Light Common Strong Heavy
    Sources

    Sublingual

    Dose ladder — Light–Heavy: same as the Oral row (dose.wiki, TripSit); no source states a Sublingual ladder

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Sublingual 10-30 min 30-60 min 2-5 hrs 4-8 hrs 2-6 hrs 7-14 hrs
    Insufflated 2-10 min 15-30 min 2-5 hrs 4-8 hrs 2-6 hrs 7-14 hrs
    Vaporized 2-5 min 10-20 min 2-5 hrs 4-8 hrs 2-6 hrs 7-14 hrs
    Oral 25-40 min - 7-14 hrs - 1-16 hrs 7-14 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.8
    Moderate 4/10

    Moderate body load with mild visuals and headspace

    Visual Intensity ×3
    5
    color enhancement color shifting brightened colour
    Headspace Depth ×3
    4
    thought connectivity time distortion confusion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    7
    vasoconstriction nausea muscle tension
    Based on reports from:
    Erowid Experience Reports
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects dose.wiki TripSit

    Positive
    Negative
    Neutral
    Positive
    Negative
    • Afterglow or fatigue
    Neutral
    • Change in perception
    Positive
    Negative
    Neutral
    • Closed/Open eye visuals

    Combinations TripSit

    Cross-Check 25P-NBOMe with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 1 report 1 neutral visit
    Trial Run 2 neutral exp #103587

    I am a cosmonaut of the fifth degree. I have experience with 2c-b, 2c-p, dmt, lsd, mdma, methylone, 25b, 25c, 25d, 25e, 25i, 25n, 25p, 5-meo-dmt. I also smoke a fair amount of medical cannabis. I have came in possession of 30 mg 2C-P-NBOMe.

    CosmonautStone · 3.2 mg insufflated
    25P-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 TripSit 📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 25P-NBOMe there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "25P-NBOMe (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    25P-NBOMe
    Unit
    µg
    Description 
    25P-NBOMe
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (µg): threshold 50-100ug · light 250-450ug · common 450-700ug · strong 700-1500ug · heavy 1500+
Insufflated dose (µg): threshold 25-50ug
Vaporized dose (µg): threshold 20-40ug
Oral dose (µg): threshold 100-250ug · light 250-450ug · common 450-700ug · strong 700-1500ug · heavy 1500ug+

Sublingual duration: onset 10-30m · come-up 0.5-1h · peak 2-5h · offset 4-8h · total 7-14h · after-effects 2-6h
Insufflated duration: onset 2-10m · come-up 15-30m · peak 2-5h · offset 4-8h · total 7-14h · after-effects 2-6h
Vaporized duration: onset 2-5m · come-up 10-20m · peak 2-5h · offset 4-8h · total 7-14h · after-effects 2-6h
Oral duration: onset 25-40m · peak 7-14h · total 7-14h · after-effects 1-16h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 575 µg (Sublingual).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.