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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-CMA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • partial dose data
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical

    Aliases: P-cma, Para-cma, Ro 4-6861

    Stimulant Research-chemical

    Summary dose.wiki TripSit

    4-CMA is a prodrug that metabolizes to 4-Chloroamphetamine (4-CA), which selectively destroys serotonergic axon terminals. Lasting mood, cognitive and sleep disturbances have been reported after single exposures. Tablets seized in Europe contained 25-150 mg active drug.

    Dose Information source varies by band

    ROA Light Heavy
    Oral 5-15mg 60+ mg (not recommended)
    Light Heavy
    Sources· 1 of 1 ladders not fully identified

    Oral

    Dose ladder — Light: DrugsPRO · Heavy: not identified

    Onset, Duration & After-effects dose.wiki

    ROA Onset Peak Offset After Effects Total
    Oral 20-60 min 1-3 hrs 2-4 hrs 2-6 hrs 3.33-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 6.4
    Strong 6/10

    Strong euphoria with moderate stimulation and sensory enhancement, mild empathy

    Empathy / Social Openness ×3
    5
    empathy enhancement increased sociability
    Euphoria / Mood Elevation ×2
    8
    physical euphoria cognitive euphoria mood lift
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    Stimulant 3.9
    Moderate 4/10

    Strong anxiety/jitters and euphoria with mild stimulation

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    8
    physical euphoria cognitive euphoria mood lift
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate vasoconstriction
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects dose.wiki

    Positive
    Negative
    Neutral
    • Neurotoxicity symptoms
    Positive
    Negative
    Positive
    Negative

    Combinations

    Cross-Check 4-CMA with another substance

    4-CMA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-CMA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    4-CMA
    Unit
    mg
    Description 
    4-CMA
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold ~5  (extrapolated) · light 5-15 · heavy 60+  (not recommended)

Oral duration: onset 0.33-1h · peak 1-3h · offset 2-4h · total 3.33-8h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.