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    5-MeO-DMT molecular structure

    5-MeO-DMT Stats & Data

    Toad Bufo 5-meo Toads Jaguar 5meodmt 5meo 5-medmt
    PubChem
    MW218.29
    FormulaC13H18N2O
    LogP1.5
    IUPAC2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
    InChIKeyZSTKHSQDNIGFLM-UHFFFAOYSA-N
    Chemical Class Substituted tryptamine
    Psychoactive Class Psychedelic
    Half-Life Unknown in humans; very rapid onset/offset suggests short distribution half‑life. Predominantly deaminated by MAO‑A; hepatic O‑demethylation via CYP2D6 yields active metabolite bufotenine.

    Pharmacology

    DrugBank
    State Solid

    Description

    5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug, as well as dimethyltryptamine and bufotenin, have been registered to be used in South America in religious and spiritual rituals.

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT1A receptor agonist (preferential affinity)
    5-HT2A receptor agonist (partial)
    5-HT2B receptor agonist
    5-HT2C receptor agonist
    5-HT1B receptor agonist
    5-HT1D receptor agonist
    Inhibitors
    Serotonin reuptake inhibitor (weak)
    Norepinephrine reuptake inhibitor (weak)

    Measured Affinities

    Guide to PHARMACOLOGY

    Measured binding and functional data for 5-MeO-DMT, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.

    Target Action Measure Value Concentration Species Source
    5-HT1F receptor HTR1F Full agonist pKi 7.4 39.81 nM Human PMID 8380639
    5-HT6 receptor Htr6 Full agonist pKi 6.9 125.89 nM Rat PMID 9798944
    5-HT2C receptor HTR2C Full agonist pKi — — Human PMID 10217294
    5-HT7 receptor Htr7 Full agonist pKi — — Rat PMID 8394362
    5-ht1e receptor HTR1E Full agonist pKi — — Human —

    Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.

    Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.

    History & Culture

    8th century–present

    5-MeO-DMT has a lengthy history of human use spanning over a millennium. Archaeological evidence from a burial site in Northern Chile, dated to approximately the 8th century A.D., revealed snuffing paraphernalia alongside traces of N,N-DMT, 5-MeO-DMT, and bufotenine. Additional archaeological sites from the same period have uncovered seeds from Anadenanthera species known to contain the compound. The substance appears as a common constituent in numerous plant species and has been employed traditionally in various psychoactive preparations across South America and the Caribbean. Indigenous groups have utilized it in intranasal snuffs including Yopo, prepared from Anadenanthera colubrina seeds, and Epena, derived from Virola sap. It has also been incorporated as an admixture in certain ayahuasca-type brews. In the early 1950s, researchers identified 5-MeO-DMT as one of the primary psychoactive components in cohoba snuffs used by peoples of the northern Amazon basin.

    1936–1959

    The compound was first synthesized in 1936 by Japanese chemists Toshio Hoshino and Kenya Shimodaira. Over two decades later, in 1959, it was isolated and identified as one of the psychoactive constituents of Anadenanthera peregrina seeds used in the preparation of Yopo snuff. While 5-MeO-DMT was initially believed to be a major contributor to the psychoactive properties of such snuffs, subsequent research has suggested this is unlikely due to its limited or sometimes negligible presence in the seeds, which instead appear to derive their effects primarily from bufotenine.

    1968–present

    The first published report identifying toad venom as a natural source of 5-MeO-DMT appeared in 1968. The Colorado River toad (Incilius alvarius, also known as Bufo alvarius) was found to produce venom containing concentrations of up to 15% 5-MeO-DMT. This discovery established the species as the only known psychoactive toad and has since led to its venom becoming a sought-after source of the compound.

    1980s–present

    Recreational and non-traditional use of 5-MeO-DMT expanded throughout the 1980s and 1990s. Alexander Shulgin documented the synthesis and psychoactive effects of the compound in his 1997 book TiHKAL ("Tryptamines I Have Known and Loved"), which also described the use of Colorado River toad venom. In contemporary times, the substance is primarily obtained in its pure synthetic form through online research chemical vendors. Recent studies have investigated its capacity to induce mystical experiences, and there is growing scientific interest in exploring potential therapeutic applications.

    Subjective Effects

    In comparison to its often relatively mild accompanying cognitive and visual effects, 5-MeO-DMT seems to have by far the most proportionally intense and overwhelming physical sensations found within the known psychedelic experience.

    Physical

    The physical effects of 5-MeO-DMT can be broken down into ten components all of which progressively intensify proportional to dosage.

    • Enhancement of tactile sensations: This particular component is perhaps the most overwhelming sensation within the entirety of the 5-MeO-DMT experience. It increases the intensity of tactile sensations to such an overwhelming extent that it induces a sustained and repeatable full body orgasm within every nerve ending across the entire body. The experience of this results in the perception of having a difficulty sustaining the act of breathing. It is worth noting, however, that this is not a genuine or dangerous experience of respiratory depression and is perfectly safe.
    • Physical euphoria
    • Nausea
    • Increased bodily control
    • Loss of motor control
    • Bodily pressures
    • Skin flushing
    • Changes in gravity
    • Loss of temperature regulation
    • Increased bodily weight
    Cognitive
    • Enhancement of current mind state
    • Mindfulness
    • Conceptual thinking
    • Connectivity of thought
    • Anxiety
    • Time distortion
    • Direct communication with the subconscious
    • States of unity and interconnectedness
    • Ego suppression, loss and death
    • Delusions
    • Amnesia
    Sensory

    In comparison to its consistently overwhelming and intense accompanying cognitive and physical effects, 5-MeO-DMT seems to have some of the most proportionally underwhelming visual effects found within the known psychedelic experience.

    Auditory
    • Enhancements
    • Distortions
    • Hallucinations
    Visual · Distortions
    • Colour shifting
    • Visual drifting: (Morphing, Breathing, Melting, Flowing) - In comparison to other psychedelics, this effect can be described as identical to DMT in its style, highly detailed, slow and smooth in motion and static in appearance.
    Visual · Enhancements
    • Visual acuity enhancement and suppression: 5-MeO-DMT is equally capable of both decreasing and increasing visual acuity. The outcome of which effect will manifest seems to be chosen almost entirely at random and is largely setting dependent.
    • Colour enhancement

    Forked from Subjective Effect Documentation by Josie Kins, September 2014. Via dose.wiki (CC0).

    Toxicity

    PsychonautWiki

    The toxicity and long-term health effects of recreational 5-MeO-DMT do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 5-MeO-DMT has a limited history of documented human usage. Anecdotal evidence suggests that there are unlikely to be any negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this substance.

    Addiction & dependence

    Like other serotonergic psychedelics, 5-MeO-DMT is considered to be non-addictive with a low abuse potential. There are no literature reports of successful attempts to train animals to self-administer 5-MeO-DMT — an animal model predictive of abuse liability — indicating that it does not have the necessary pharmacology to either initiate or maintain dependence. Tolerance to the effects of 5-MeO-DMT is built almost immediately after ingestion.

    Effect Profile

    Curated + 325 Reports
    Psychedelic 8.8

    Strong visuals, headspace, auditory effects, and body load

    Visual Intensity×3
    10102.1
    Headspace Depth×3
    107.64.2
    Auditory Effects×1
    10102.2
    Body Load / Somatic Effects×1
    105.64.7
    Catalog Erowid BlueLight

    Duration Timeline

    Bluelight
    Onset Comeup Peak Offset After Effects
    Smoked
    0 minutes
    0 minutes
    6-12 minutes
    12-18 minutes
    12 minutes - 1.0 hours
    Total: 30 minutes
    Insufflated
    3-7 minutes
    4-15 minutes
    30-45 minutes
    15-30 minutes
    1-3 hours
    Total: 2-3 hours
    Oral
    10-30 minutes
    19-40 minutes
    30 minutes - 1.5 hours
    1-2 hours
    1-3 hours

    Community Effects

    TripSit
    Positive
    euphoria introspection
    Negative
    nausea vomiting anxiety tachycardia

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; very rapid onset/offset suggests short distribution half‑life. Predominantly deaminated by MAO‑A; hepatic O‑demethylation via CYP2D6 yields active metabolite bufotenine.
    Addiction Potential
    Low; not considered habit-forming. Compulsive use patterns are rare, and there is no evidence for physical dependence.

    Tolerance Decay

    Full tolerance 0.5h Half tolerance 7d Baseline ~14d

    Users frequently report marked acute tolerance if re-dosed within the same session; effects are often blunted or dysphoric. Cross‑tolerance with other serotonergic psychedelics is plausible via 5‑HT2A down‑regulation, but quantitative data are limited; estimates here are conservative and anecdotal.

    Cross-Tolerances

    psilocybin
    LSD
    N,N‑DMT

    Experience Report Analysis

    Erowid BlueLight
    374 Reports
    267 Single-substance
    1996–2025 Date Range
    96 With Age Data
    30 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid + Bluelight

    Effects aggregated from 317 experience reports (267 single-substance Erowid + 58 Bluelight)

    317 Reports
    151 Effects Detected
    59 Positive
    53 Adverse
    39 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

    Positive Effects 59

    Visual Distortions 45.4% (95% interval 40 to 51 percent) 74%
    Euphoria 36.9% (95% interval 32 to 42 percent) 87%
    Stimulation 29.3% (95% interval 25 to 35 percent) 80%
    Color Enhancement 28.7% (95% interval 24 to 34 percent) 82%
    Awe 28.0% (95% interval 18 to 42 percent) 86%
    Empathy 26.5% (95% interval 22 to 32 percent) 80%
    Mystical Quality 26.0% (95% interval 16 to 40 percent) 85%
    Music Enhancement 24.3% (95% interval 20 to 29 percent) 86%
    Peace 22.0% (95% interval 13 to 35 percent) 84%
    Closed-Eye Visuals 16.7% (95% interval 13 to 21 percent) 86%
    Oneness 16.0% (95% interval 8 to 28 percent) 88%
    Bliss 16.0% (95% interval 8 to 28 percent) 89%
    Introspection 15.8% (95% interval 12 to 20 percent) 80%
    Geometric Imagery 14.0% (95% interval 7 to 26 percent) 86%
    Joy 14.0% (95% interval 7 to 26 percent) 84%
    Body High 12.7% (95% interval 9 to 17 percent) 84%
    Fractal Imagery 12.0% (95% interval 6 to 24 percent) 88%
    Visual Trails 12.0% (95% interval 6 to 24 percent) 83%
    Focus Enhancement 11.7% (95% interval 9 to 16 percent) 75%
    Tactile Enhancement 10.5% (95% interval 7 to 15 percent) 70%

    Adverse Effects 53

    Anxiety 57.1% (95% interval 52 to 62 percent) 84%
    Body Load 50.0% (95% interval 37 to 63 percent) 82%
    Fear 48.0% (95% interval 35 to 62 percent) 91%
    Depersonalization 32.0% (95% interval 21 to 46 percent) 83%
    Thought Disorganization 30.0% (95% interval 19 to 44 percent) 85%
    Confusion 27.1% (95% interval 22 to 32 percent) 83%
    Nausea 24.0% (95% interval 20 to 29 percent) 86%
    Panic 24.0% (95% interval 14 to 37 percent) 89%
    Pressure 14.0% (95% interval 7 to 26 percent) 87%
    Vomiting 14.0% (95% interval 7 to 26 percent) 92%
    Increased Heart Rate 13.1% (95% interval 10 to 18 percent) 70%
    Pain Enhancement 12.0% (95% interval 6 to 24 percent) 90%
    Timelessness 10.0% (95% interval 4 to 21 percent) 87%
    Entity Imagery 10.0% (95% interval 4 to 21 percent) 83%
    Memory Suppression 9.8% (95% interval 7 to 14 percent) 81%
    Dysphoria 8.0% (95% interval 3 to 19 percent) 88%
    Motor Impairment 7.9% (95% interval 5 to 11 percent) 84%
    Pupil Dilation 6.4% (95% interval 4 to 10 percent) 70%
    Sweating 6.3% (95% interval 4 to 10 percent) 80%
    Language Comprehension Suppression 6.0% (95% interval 2 to 16 percent) 87%
    ⚠ Seizure 3.4% (95% interval 2 to 6 percent) 70%
    ⚠ Psychosis 3.0% (95% interval 2 to 6 percent) 70%
    ⚠ Difficulty Breathing 2.0% (95% interval 0 to 10 percent) 70%
    Show 30 more adverse effects
    Out-Of-Body Experience 6.0% (95% interval 2 to 16 percent) 88%
    Thought Suppression 6.0% (95% interval 2 to 16 percent) 83%
    Tinnitus 6.0% (95% interval 2 to 16 percent) 90%
    Headache 6.0% (95% interval 2 to 16 percent) 82%
    Muscle Tension 4.1% (95% interval 2 to 7 percent) 70%
    Paranoia 4.0% (95% interval 1 to 14 percent) 80%
    Involuntary Movements 4.0% (95% interval 1 to 14 percent) 85%
    Sadness 4.0% (95% interval 1 to 14 percent) 85%
    Amnesia 4.0% (95% interval 1 to 14 percent) 82%
    Double Vision 4.0% (95% interval 1 to 14 percent) 85%
    Heart Rate Increase 4.0% (95% interval 1 to 14 percent) 95%
    Jaw Clenching 3.8% (95% interval 2 to 6 percent) 85%
    Hopelessness 2.0% (95% interval 0 to 10 percent) 80%
    Derealization 2.0% (95% interval 0 to 10 percent) 85%
    Disinhibition 2.0% (95% interval 0 to 10 percent) 85%
    Pareidolia 2.0% (95% interval 0 to 10 percent) 90%
    Insomnia 2.0% (95% interval 0 to 10 percent) 75%
    Visual Snow 2.0% (95% interval 0 to 10 percent) 85%
    Stomach Cramps 2.0% (95% interval 0 to 10 percent) 75%
    Grief 2.0% (95% interval 0 to 10 percent) 85%
    Sorrow 2.0% (95% interval 0 to 10 percent) 85%
    Delusion 2.0% (95% interval 0 to 10 percent) 90%
    Taste Distortion 2.0% (95% interval 0 to 10 percent) 90%
    Blurred Vision 2.0% (95% interval 0 to 10 percent) 85%
    Weakness 2.0% (95% interval 0 to 10 percent) 90%
    Disappointment 2.0% (95% interval 0 to 10 percent) 80%
    Perceived Size Change 2.0% (95% interval 0 to 10 percent) 85%
    Emotional Suppression 2.0% (95% interval 0 to 10 percent) 65%
    Shadow Imagery 2.0% (95% interval 0 to 10 percent) 75%
    Loneliness 2.0% (95% interval 0 to 10 percent) 75%

    Dose-Response Correlation

    How effect frequency changes across dose levels. Whiskers, and the numbers' hover text, give each figure's 95% interval.

    Not drawn, too few reports (a dose tier needs 20): Insufflated Common (n=18). Why 20?

    View data table
    Effect Common (n=35) Strong (n=26) Heavy (n=30)
    Anxiety 62.9% (95% interval 46 to 77 percent) 61.5% (95% interval 42 to 78 percent) 76.7% (95% interval 59 to 88 percent)
    Visual Distortions 54.3% (95% interval 38 to 70 percent) 53.8% (95% interval 36 to 71 percent) 50.0% (95% interval 33 to 67 percent)
    Euphoria 45.7% (95% interval 30 to 62 percent) 38.5% (95% interval 22 to 58 percent) 46.7% (95% interval 30 to 64 percent)
    Empathy 40.0% (95% interval 26 to 56 percent) 26.9% (95% interval 14 to 46 percent) 26.7% (95% interval 14 to 44 percent)
    Stimulation 31.4% (95% interval 19 to 48 percent) 38.5% (95% interval 22 to 58 percent) 33.3% (95% interval 19 to 51 percent)
    Auditory Effects 28.6% (95% interval 16 to 45 percent) 38.5% (95% interval 22 to 58 percent) 16.7% (95% interval 7 to 34 percent)
    Color Enhancement 22.9% (95% interval 12 to 39 percent) 38.5% (95% interval 22 to 58 percent) 30.0% (95% interval 17 to 48 percent)
    Confusion 28.6% (95% interval 16 to 45 percent) 30.8% (95% interval 16 to 50 percent) 13.3% (95% interval 5 to 30 percent)
    Music Enhancement 25.7% (95% interval 14 to 42 percent) 30.8% (95% interval 16 to 50 percent) 13.3% (95% interval 5 to 30 percent)
    Introspection 22.9% (95% interval 12 to 39 percent) 30.8% (95% interval 16 to 50 percent) 10.0% (95% interval 4 to 26 percent)
    Nausea 28.6% (95% interval 16 to 45 percent) 19.2% (95% interval 8 to 38 percent) 20.0% (95% interval 10 to 37 percent)
    Dissociation 25.7% (95% interval 14 to 42 percent) 26.9% (95% interval 14 to 46 percent) 26.7% (95% interval 14 to 44 percent)
    Hospital 5.7% (95% interval 2 to 19 percent) 15.4% (95% interval 6 to 34 percent) 26.7% (95% interval 14 to 44 percent)
    Increased Heart Rate 25.7% (95% interval 14 to 42 percent) 11.5% (95% interval 4 to 29 percent) 6.7% (95% interval 2 to 21 percent)
    Ego Dissolution 22.9% (95% interval 12 to 39 percent) 11.5% (95% interval 4 to 29 percent) 23.3% (95% interval 12 to 41 percent)

    Subjective Effect Ontology

    Experience Reports

    Structured effect tags extracted from 424 Erowid & Bluelight experience reports using a controlled vocabulary of 220+ canonical effects across 15 domains.

    Auditory

    music enhancement 121 28.5% (95% interval 24 to 33 percent)

    Cognitive

    confusion 124 29.3% (95% interval 25 to 34 percent) focus enhancement 100 23.6% (95% interval 20 to 28 percent)

    Emotional

    anxiety 248 58.5% (95% interval 54 to 63 percent) euphoria 164 38.7% (95% interval 34 to 43 percent) empathy 130 30.7% (95% interval 26 to 35 percent)

    Gastrointestinal

    nausea 113 26.6% (95% interval 23 to 31 percent)

    Motor

    stimulation 129 30.4% (95% interval 26 to 35 percent)

    Tactile

    tactile enhancement 100 26.7% (95% interval 22 to 31 percent)

    Visual

    visual distortions 223 52.6% (95% interval 48 to 57 percent) color enhancement 137 32.3% (95% interval 28 to 37 percent)

    11 unique effects extracted · Derived from Erowid & Bluelight reports

    Dose–Effect Mapping

    Experience Reports

    How reported effects shift across dose tiers, based on 267 single-substance experience reports. The shaded band on each bar is its 95% interval. An arrow (↑ ↓) marks a change between the lowest and highest tier that count an effect only when the gap is bigger than chance would explain; ~ means no clear change. How changes are called

    Not drawn, too few reports (a dose tier needs 20): Insufflated Common (n=18). Why 20?

    Smoked dose range: 8.0–20.0 mg (median 10.0 mg)
    Effect Common (n=35) Strong (n=26) Heavy (n=30) Change with dose
    anxiety
    63% (95% interval 46 to 77 percent)
    62% (95% interval 42 to 78 percent)
    77% (95% interval 59 to 88 percent)
    (no clear change: +14 points from Common to Heavy, 95% interval −9 to +34)
    visual distortions
    54% (95% interval 38 to 70 percent)
    54% (95% interval 36 to 71 percent)
    50% (95% interval 33 to 67 percent)
    (no clear change: −4 points from Common to Heavy, 95% interval −27 to +19)
    euphoria
    46% (95% interval 30 to 62 percent)
    38% (95% interval 22 to 58 percent)
    47% (95% interval 30 to 64 percent)
    (no clear change: +1 points from Common to Heavy, 95% interval −22 to +24)
    empathy
    40% (95% interval 26 to 56 percent)
    27% (95% interval 14 to 46 percent)
    27% (95% interval 14 to 44 percent)
    (no clear change: −13 points from Common to Heavy, 95% interval −34 to +10)
    stimulation
    31% (95% interval 19 to 48 percent)
    38% (95% interval 22 to 58 percent)
    33% (95% interval 19 to 51 percent)
    (no clear change: +2 points from Common to Heavy, 95% interval −20 to +24)
    auditory effects
    29% (95% interval 16 to 45 percent)
    38% (95% interval 22 to 58 percent)
    17% (95% interval 7 to 34 percent)
    (no clear change: −12 points from Common to Heavy, 95% interval −31 to +9)
    color enhancement
    23% (95% interval 12 to 39 percent)
    38% (95% interval 22 to 58 percent)
    30% (95% interval 17 to 48 percent)
    (no clear change: +7 points from Common to Heavy, 95% interval −14 to +28)
    confusion
    29% (95% interval 16 to 45 percent)
    31% (95% interval 16 to 50 percent)
    13% (95% interval 5 to 30 percent)
    (no clear change: −15 points from Common to Heavy, 95% interval −34 to +5)
    music enhancement
    26% (95% interval 14 to 42 percent)
    31% (95% interval 16 to 50 percent)
    13% (95% interval 5 to 30 percent)
    (no clear change: −12 points from Common to Heavy, 95% interval −31 to +8)
    introspection
    23% (95% interval 12 to 39 percent)
    31% (95% interval 16 to 50 percent)
    10% (95% interval 4 to 26 percent)
    (no clear change: −13 points from Common to Heavy, 95% interval −30 to +6)
    nausea
    29% (95% interval 16 to 45 percent)
    19% (95% interval 8 to 38 percent)
    20% (95% interval 10 to 37 percent)
    (no clear change: −9 points from Common to Heavy, 95% interval −28 to +13)
    dissociation
    26% (95% interval 14 to 42 percent)
    27% (95% interval 14 to 46 percent)
    27% (95% interval 14 to 44 percent)
    (no clear change: +1 points from Common to Heavy, 95% interval −20 to +22)
    hospital
    6% (95% interval 2 to 19 percent)
    15% (95% interval 6 to 34 percent)
    27% (95% interval 14 to 44 percent)
    (+21 points from Common to Heavy, 95% interval +3 to +39)
    increased heart rate
    26% (95% interval 14 to 42 percent)
    12% (95% interval 4 to 29 percent)
    7% (95% interval 2 to 21 percent)
    (−19 points from Common to Heavy, 95% interval −36 to −0.4)
    ego dissolution
    23% (95% interval 12 to 39 percent)
    12% (95% interval 4 to 29 percent)
    23% (95% interval 12 to 41 percent)
    (no clear change: +0.4 points from Common to Heavy, 95% interval −19 to +21)
    closed-eye visuals
    17% (95% interval 8 to 33 percent)
    8% (95% interval 2 to 24 percent)
    20% (95% interval 10 to 37 percent)
    (no clear change: +3 points from Common to Heavy, 95% interval −16 to +22)
    tactile enhancement —
    19% (95% interval 8 to 38 percent)
    13% (95% interval 5 to 30 percent)
    (no clear change: −6 points from Strong to Heavy, 95% interval −26 to +14)
    focus enhancement
    17% (95% interval 8 to 33 percent)
    8% (95% interval 2 to 24 percent)
    — (no clear change: −9 points from Common to Strong, 95% interval −26 to +9)
    body high
    11% (95% interval 4 to 26 percent)
    15% (95% interval 6 to 34 percent)
    — (no clear change: +4 points from Common to Strong, 95% interval −13 to +23)
    memory suppression —
    15% (95% interval 6 to 34 percent)
    7% (95% interval 2 to 21 percent)
    (no clear change: −9 points from Strong to Heavy, 95% interval −28 to +9)

    Showing top 20 of 30 effects

    Risk Escalation

    Sentiment Analysis

    Average frequency of positive vs adverse effects across dose tiers. A tier's average is the mean share of the effects counted in that tier, not a share of reports, and its range is a deliberately wide 95% interval. A tier with more reports also counts rarer effects, which pulls its average down, so compare single effects in the breakdown rather than these averages. There, the shaded band on each bar is its 95% interval, and Change is marked up or down only when the gap between two tiers is bigger than chance would explain. How changes are called

    Common n=35
    10 positive 28.9% (95% interval 17 to 45 percent) 8 adverse 21.8% (95% interval 13 to 36 percent)
    Strong n=26
    11 positive 28.0% (95% interval 15 to 46 percent) 8 adverse 20.2% (95% interval 10 to 38 percent)
    Heavy n=30
    11 positive 24.2% (95% interval 13 to 41 percent) 9 adverse 17.4% (95% interval 10 to 32 percent)
    View effect breakdown

    Adverse Effects

    Effect Common (n=35) Strong (n=26) Heavy (n=30) Change
    Anxiety
    63% (95% interval 46 to 77 percent)
    62% (95% interval 42 to 78 percent)
    77% (95% interval 59 to 88 percent)
    no clear change (no clear change: +14 points from Common to Heavy, 95% interval −9 to +34)
    Confusion
    29% (95% interval 16 to 45 percent)
    31% (95% interval 16 to 50 percent)
    13% (95% interval 5 to 30 percent)
    no clear change (no clear change: −15 points from Common to Heavy, 95% interval −34 to +5)
    Nausea
    29% (95% interval 16 to 45 percent)
    19% (95% interval 8 to 38 percent)
    20% (95% interval 10 to 37 percent)
    no clear change (no clear change: −9 points from Common to Heavy, 95% interval −28 to +13)
    Increased Heart Rate
    26% (95% interval 14 to 42 percent)
    12% (95% interval 4 to 29 percent)
    7% (95% interval 2 to 21 percent)
    −19 pts (−19 points from Common to Heavy, 95% interval −36 to −0.4)
    Memory Suppression —
    15% (95% interval 6 to 34 percent)
    7% (95% interval 2 to 21 percent)
    no clear change (no clear change: −9 points from Strong to Heavy, 95% interval −28 to +9)
    Motor Impairment
    11% (95% interval 4 to 26 percent)
    8% (95% interval 2 to 24 percent)
    7% (95% interval 2 to 21 percent)
    no clear change (no clear change: −5 points from Common to Heavy, 95% interval −20 to +11)
    Sweating
    6% (95% interval 2 to 19 percent)
    8% (95% interval 2 to 24 percent)
    10% (95% interval 4 to 26 percent)
    no clear change (no clear change: +4 points from Common to Heavy, 95% interval −10 to +20)
    Jaw Clenching
    6% (95% interval 2 to 19 percent)
    —
    10% (95% interval 4 to 26 percent)
    no clear change (no clear change: +4 points from Common to Heavy, 95% interval −10 to +20)
    Seizure —
    8% (95% interval 2 to 24 percent)
    — —
    Pupil Dilation — —
    7% (95% interval 2 to 21 percent)
    —
    Headache
    6% (95% interval 2 to 19 percent)
    — — —

    Positive Effects

    Effect Common (n=35) Strong (n=26) Heavy (n=30) Change
    Visual Distortions
    54% (95% interval 38 to 70 percent)
    54% (95% interval 36 to 71 percent)
    50% (95% interval 33 to 67 percent)
    no clear change (no clear change: −4 points from Common to Heavy, 95% interval −27 to +19)
    Euphoria
    46% (95% interval 30 to 62 percent)
    38% (95% interval 22 to 58 percent)
    47% (95% interval 30 to 64 percent)
    no clear change (no clear change: +1 points from Common to Heavy, 95% interval −22 to +24)
    Empathy
    40% (95% interval 26 to 56 percent)
    27% (95% interval 14 to 46 percent)
    27% (95% interval 14 to 44 percent)
    no clear change (no clear change: −13 points from Common to Heavy, 95% interval −34 to +10)
    Stimulation
    31% (95% interval 19 to 48 percent)
    38% (95% interval 22 to 58 percent)
    33% (95% interval 19 to 51 percent)
    no clear change (no clear change: +2 points from Common to Heavy, 95% interval −20 to +24)
    Color Enhancement
    23% (95% interval 12 to 39 percent)
    38% (95% interval 22 to 58 percent)
    30% (95% interval 17 to 48 percent)
    no clear change (no clear change: +7 points from Common to Heavy, 95% interval −14 to +28)
    Music Enhancement
    26% (95% interval 14 to 42 percent)
    31% (95% interval 16 to 50 percent)
    13% (95% interval 5 to 30 percent)
    no clear change (no clear change: −12 points from Common to Heavy, 95% interval −31 to +8)
    Introspection
    23% (95% interval 12 to 39 percent)
    31% (95% interval 16 to 50 percent)
    10% (95% interval 4 to 26 percent)
    no clear change (no clear change: −13 points from Common to Heavy, 95% interval −30 to +6)
    Closed-Eye Visuals
    17% (95% interval 8 to 33 percent)
    8% (95% interval 2 to 24 percent)
    20% (95% interval 10 to 37 percent)
    no clear change (no clear change: +3 points from Common to Heavy, 95% interval −16 to +22)
    Tactile Enhancement —
    19% (95% interval 8 to 38 percent)
    13% (95% interval 5 to 30 percent)
    no clear change (no clear change: −6 points from Strong to Heavy, 95% interval −26 to +14)
    Focus Enhancement
    17% (95% interval 8 to 33 percent)
    8% (95% interval 2 to 24 percent)
    — no clear change (no clear change: −9 points from Common to Strong, 95% interval −26 to +9)
    Body High
    11% (95% interval 4 to 26 percent)
    15% (95% interval 6 to 34 percent)
    — no clear change (no clear change: +4 points from Common to Strong, 95% interval −13 to +23)
    Open-Eye Visuals — —
    13% (95% interval 5 to 30 percent)
    —
    Creativity Enhancement — —
    10% (95% interval 4 to 26 percent)
    —

    Dosage Distribution

    Dose distribution from experience reports, one dose per report (the first listed). Values above Q3 + 3×IQR are left out as outliers.

    Smoked

    Median: 10.0 mg IQR: 8.0–20.0 mg n=132 1 outlier left out

    Insufflated

    Median: 12.0 mg IQR: 10.0–20.0 mg n=50 1 outlier left out

    Real-World Dose Distribution

    62K Doses

    From 351 individual dose entries. Values above Q3 + 3×IQR are left out as outliers.

    Intramuscular (n=5)

    Median: 4.0mg 25th: 2.5mg 75th: 4.0mg 90th: 58.6mg

    Smoked (n=199)

    Median: 10.0mg 25th: 8.0mg 75th: 19.0mg 90th: 25.0mg

    Insufflated (n=73)

    Median: 12.0mg 25th: 10.0mg 75th: 20.0mg 90th: 27.2mg

    Intravenous (n=5)

    Median: 6.0mg 25th: 2.8mg 75th: 8.0mg 90th: 9.2mg

    Oral (n=7)

    Median: 25.0mg 25th: 16.25mg 75th: 30.0mg 90th: 34.0mg

    Common Combinations

    Most co-occurring substances, as a share of all 374 reports filed under 5-MeO-DMT; whiskers are 95% intervals

    Form / Preparation

    Most common forms and preparations, as a share of the 291 reports that give one; whiskers are 95% intervals

    Body-Weight Dosing

    Dose per kg of body weight, one dose per report (the first listed), from reports giving a weight of 30–250 kg. Values above Q3 + 3×IQR are left out as outliers.

    Smoked

    Median: 0.16 mg/kg IQR: 0.11–0.251 mg/kg n=126 2 outliers left out

    Insufflated

    Median: 0.169 mg/kg IQR: 0.134–0.238 mg/kg n=49 1 outlier left out

    Redose Patterns

    Redosing behavior across 301 reports

    8.6% (95% interval 6 to 12 percent) Redosed
    1.1 Avg Doses
    10m Median Interval

    Legal Status

    Country Status Notes
    Australia Schedule 9 Classified as a prohibited substance under the Poisons Standard as a structural analog of N,N-dimethyltryptamine (DMT). No therapeutic use is recognized.
    Austria Illegal (SMG) Prohibited under the Suchtmittelgesetz (Narcotics Act) as an ether of N,N-DMT. Possession, production, and sale are illegal without authorization.
    Belgium Uncontrolled (unconfirmed) Reportedly not explicitly controlled under Belgian law, although DMT itself is scheduled under the 1971 UN Convention. This status remains unconfirmed.
    Brazil Illegal Possession, production, and sale are prohibited under Portaria SVS/MS nº 344.
    Canada Unscheduled Not scheduled under the Controlled Drugs and Substances Act. Possession and sale are not specifically prohibited under federal drug law.
    China Controlled Classified as a controlled substance effective October 2015 under national drug regulations.
    Czech Republic Legal Not listed in Government Regulation n. 463/2013 (Nařízení vlády č. 463/2013 Sb), making it legal to possess and sell.
    Denmark Restricted Legally restricted to medical or scientific purposes since December 2004. General possession and sale are prohibited.
    Finland Illegal Banned in December 2014 under a government regulation that prohibited over 100 psychoactive chemicals.
    Germany Anlage I BtMG Listed in Schedule I of the Betäubungsmittelgesetz (Narcotics Act) since 2000. Manufacturing, possession, import, export, purchase, sale, and distribution without a license are prohibited.
    Greece Controlled Became a controlled substance on February 18, 2003, as recorded in the EU Legal Database.
    Japan Designated Substance Controlled as a Shitei-Yakubutsu (Designated Substance) under the Pharmaceutical Affairs Law. Possession and sale are illegal without authorization.
    Latvia Schedule I Listed as a Schedule I controlled substance under national drug legislation. Possession and distribution are prohibited.
    Netherlands Ambiguous (potentially List I) While not explicitly named in the Opium List, it may be considered a List I controlled substance as an ether of bufotenin. Despite this legal ambiguity, it reportedly remains available through online research chemical vendors.
    New Zealand Class A (Schedule I) Classified as a Class A controlled substance, carrying the most severe legal penalties for possession and distribution in New Zealand.
    Romania Illegal (Analogue Act) Prohibited under the controlled substance analogue act since February 2010. Production and sale are illegal.
    Russia Controlled Became a controlled substance in October 2011 under federal drug legislation.
    South Africa Ambiguous Not explicitly listed under the Drug and Drug Trafficking Act No. 140 of 1992. However, it could potentially be controlled as an ether of bufotenin or DMT, since ethers and esters of listed substances are also considered controlled.
    Sweden Health Hazard Classified under the Act on the Prohibition of Certain Goods Dangerous to Health (Lagen om förbud mot vissa hälsofarliga varor) via regulation SFS 2004:696 effective October 1, 2004. Sale and possession are prohibited.
    Switzerland Controlled (Verzeichnis E) Specifically named as a controlled substance in Verzeichnis E (Schedule E) of Swiss narcotics legislation.
    Turkey Illegal Classified as a controlled drug since December 2013. Possession, production, supply, and import are prohibited.
    Ukraine Controlled Listed as a controlled substance under Ukrainian drug legislation.
    United Kingdom Class A (Schedule I) Controlled under the Misuse of Drugs Act 1971 as a Class A drug because it is an ether of 5-HO-DMT (bufotenin), which falls under the tryptamine catch-all clause. Buying or possessing without a license is illegal.
    United States Schedule I Added to Schedule I of the Controlled Substances Act effective January 19, 2011. Manufacturing, buying, possessing, or distributing without a DEA license is illegal. Several states including Florida, Louisiana, Nebraska, Oklahoma, and South Dakota had independently scheduled it prior to federal action.

    Harm Reduction

    drugs.wiki

    5‑MeO‑DMT is extremely potent and fast‑acting; vapourized breakthrough effects can occur from as little as 3–5 mg in some users, so pre-measuring on a 0.001 g scale and avoiding “eyeballing” is critical for safety. Acute, short-lived non‑responsiveness and loss of motor control are frequently reported above ~8–10 mg smoked/vaporized or ~15–20 mg insufflated; a sober sitter and a clear, padded space reduce injury risk during the 3–10 minute peak. Combining 5‑MeO‑DMT with MAO inhibitors (harmala alkaloids or pharmaceutical MAOIs) greatly elevates systemic 5‑MeO‑DMT and bufotenine exposure and has been implicated in severe toxicity; avoid this combination entirely. Serotonergic medications and agents (e.g., SSRIs/SNRIs, MDMA, tramadol, DXM, linezolid, 5‑HTP) can raise the risk of serotonin syndrome; spacing and medical advice are prudent if prescribed such drugs. Depressants like alcohol, opioids, or benzodiazepines add sedation and aspiration risk during peak non‑responsiveness; at least one fatality following insufflation involved concurrent heavy alcohol use. Nasal use is better suited to salt forms (HCl/fumarate); freebase burns and absorbs poorly, and onset is slower with a more extended after‑period. Oral 5‑MeO‑DMT is generally inactive without MAO‑A inhibition; because MAOIs substantially increase risk, oral/“pharmahuasca” approaches with 5‑MeO‑DMT are not recommended. “Bufo”/toad secretion contains additional, variably present compounds and has inconsistent potency; synthetic 5‑MeO‑DMT permits accurate dosing and avoids wildlife/ethical harms. Start with the lowest end of dose ranges, use a temperature‑controlled vaporization method (avoid direct flame charring), and pre‑arrange recovery position guidance with a sitter in case of vomiting. Individuals with cardiovascular disease, seizure history, or unstable psychiatric conditions should avoid use; prolonged anxiety or destabilization can occur in some users and may require integration support. Expect rapid tolerance within a session; redosing during the peak typically produces diminished or dysphoric effects, and spacing sessions by at least several days is prudent.

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