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    Allylescaline molecular structure

    Allylescaline Stats & Data

    Al Allylmescaline
    NPS DataHub
    MW237.3
    FormulaC13H19NO3
    CAS39201-75-7
    IUPAC2-(3,5-dimethoxy-4-prop-2-enoxyphenyl)ethanamine
    SMILESNCCc1cc(OC)c(OCC=C)c(OC)c1
    InChIKeyJNUAYHHGCXYBHX-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Scaline phenethylamine
    Psychoactive Class Psychedelic

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist (partial)
    5-HT2B receptor agonist (partial)
    5-HT2C receptor agonist (partial)

    History & Culture

    Allylescaline was first documented in the scientific literature by Czech chemist Otakar Leminger in 1972. The compound received broader attention when American chemist Alexander Shulgin synthesized and characterized its psychoactive effects, publishing his findings in the 1991 book PiHKAL: A Chemical Love Story. In PiHKAL, Shulgin described allylescaline's subjective effects and established dosage parameters based on his bioassay methodology. The compound remained relatively obscure for over two decades following PiHKAL's publication. It emerged on the research chemical market in 2013, when it was identified as a novel designer drug being sold online. This appearance prompted regulatory responses in several countries during the mid-2010s.

    Subjective Effects

    Physical
    • Spontaneous tactile sensations
    • Stimulation
    • Nausea
    • Tactile enhancement
    • Bodily control enhancement
    • Pupil dilation
    • Wakefulness
    • Physical euphoria
    Cognitive
    • Emotion enhancement
    • Thought acceleration
    • Novelty enhancement
    • Time distortion
    • Analysis enhancement
    • Personal bias suppression
    • Conceptual thinking
    • Immersion enhancement
    • Memory suppression
    • Thought loops
    • Thought disorganization
    • Unity and interconnectedness
    Sensory
    Auditory
    • Enhancements
    • Distortions
    • Hallucinations
    Visual · Distortions
    • Drifting: (melting, flowing, breathing and morphing)
    • Tracers
    • After images
    • Symmetrical texture repetition
    • Colour shifting
    Visual · Enhancements
    • Acuity enhancement
    • Colour enhancement
    • Pattern recognition enhancement
    Visual · Hallucinatory States
    • Transformations

    Forked from Subjective Effect Documentation work by Josie Kins, August 2016. Via dose.wiki (CC0).

    Toxicity

    PsychonautWiki

    The toxicity and long-term health effects of recreational allylescaline use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because allylescaline is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried allylescaline suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.

    Effect Profile

    Curated + 8 Reports
    Psychedelic 9.2

    Strong visuals, headspace, and auditory effects with moderate body load

    Visual Intensity×3
    10
    Headspace Depth×3
    10
    Auditory Effects×1
    10
    Body Load / Somatic Effects×1
    6

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Experience Report Analysis

    Erowid
    20 Reports
    8 Single-substance
    2012–2023 Date Range
    18 With Age Data
    7 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 8 experience reports (8 single-substance Erowid)

    8 Reports
    7 Effects Detected
    6 Positive
    1 Adverse
    0 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

    Too few reports for bars: these effects come from 8 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    Positive Effects 6

    Visual Distortions 6 of 8 70%
    Color Enhancement 4 of 8 70%
    Closed-Eye Visuals 4 of 8 70%
    Empathy 3 of 8 70%
    Stimulation 3 of 8 70%
    Body High 3 of 8 70%

    Adverse Effects 1

    Anxiety 3 of 8 70%

    Dosage Distribution

    Dose distribution from experience reports, one dose per report (the first listed). Values above Q3 + 3×IQR are left out as outliers.

    Median: 27.0 mg IQR: 17.5–45.0 mg n=15

    Real-World Dose Distribution

    62K Doses

    From 33 individual dose entries. Values above Q3 + 3×IQR are left out as outliers.

    Oral (n=30)

    Median: 15.0mg 25th: 10.0mg 75th: 25.0mg 90th: 41.0mg

    Common Combinations

    Most co-occurring substances, as a share of all 20 reports filed under Allylescaline; whiskers are 95% intervals

    Form / Preparation

    Most common forms and preparations, as a share of the 15 reports that give one

    Too few reports for bars: these forms come from 15 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    • Powder / Crystals 7 of 15
    • Capsule 6 of 15
    • Liquid 2 of 15

    Body-Weight Dosing

    Dose per kg of body weight, one dose per report (the first listed), from reports giving a weight of 30–250 kg. Values above Q3 + 3×IQR are left out as outliers.

    Median: 0.344 mg/kg IQR: 0.235–0.586 mg/kg n=15

    Redose Patterns

    Redosing behavior across 15 reports

    4 of 15 Redosed
    1.6 Avg Doses
    70m Median Interval

    Too few reports for a chart: redosing is known from 15 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

    • Single dose 11 of 15
    • Redosed 4 of 15

    Legal Status

    Country Status Notes
    Germany Anlage I BtMG Controlled under the Narcotics Act (Betäubungsmittelgesetz) Schedule I since February 1, 1997, listed as '4-Allyloxy-3,5-dimethoxy-phenethylazan'. Manufacturing, possession, import, export, purchase, sale, procurement, and dispensation without a license are prohibited.
    Japan Controlled substance Designated as a controlled substance effective March 25, 2015.
    Sweden Illegal Classified as an illegal substance since January 2016.
    Switzerland Controlled (Verzeichnis E) Specifically named and controlled under Verzeichnis E of Swiss narcotics legislation.
    United Kingdom Illegal (Psychoactive Substances Act) Production, supply, and import prohibited under the Psychoactive Substances Act 2016, which came into effect on May 26, 2016.
    United States Unscheduled Not directly scheduled under the Controlled Substances Act. However, due to structural similarities with mescaline, sale for human consumption or use for illicit purposes could potentially be prosecuted under the Federal Analogue Act.
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