Arimistane
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Estrovade, 3-deoxy-7-oxo-dhea, Androst-3,5-dien-7,17-dione, 3,5-androstadiene-7,17-dione
Summary
Arimistane is a suicide aromatase inhibitor banned by WADA and considered unsafe by the FDA for use as a dietary supplement. Run baseline labs before use, then retest estradiol (E2-sensitive LC-MS/MS), total/free testosterone, SHBG, AST/ALT, and lipid panel every 2 weeks during use. Limit cycles to 6 weeks maximum followed by at least 4 weeks off to restore aromatase enzyme levels.
Dose Information
Dose basis. Community-reported only; no human pharmacokinetics or dosing trials located in the literature. Product purity/potency varies widely across supplement brands. Anecdotal practice to speed onset; formal bioavailability data are lacking. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 12.5-25mg | 25-50mg | 50-75mg | 75mg+ |
| Sublingual | 10-15mg | 15-30mg | 30-45mg | 45mg+ |
| Transdermal | 25-50mg | 50-75mg | 75-100mg | 100mg+ |
Sources
Oral
Dose ladder — Drugs.WikiSublingual
Dose ladder — Drugs.WikiTransdermal
Dose ladder — Drugs.WikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 4-6 hrs | 12-24 hrs | 17.5-33 hrs |
| Sublingual | 15-30 min | 45-90 min | 3-5 hrs | 12-24 hrs | 16-31 hrs |
| Transdermal | - | - | 4-6 hrs | 12-24 hrs | 24-48 hrs |
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
No formal tolerance data. Timings reflect community patterns (weeks of continuous daily use leading to reduced responsiveness and increased side effects), not receptor-level tolerance. Interpret as practical guidance rather than a pharmacologic model.
Cross-Tolerances
Effects
Effect glossary — · full glossary
- Elevated aggression/drive
- Mood changes
Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Arimistane there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Arimistane Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 12.5 · light 12.5-25 · common 25-50 · strong 50-75 · heavy 75+ Sublingual dose (mg): threshold 5-10 · light 10-15 · common 15-30 · strong 30-45 · heavy 45+ Transdermal dose (mg): threshold 25 · light 25-50 · common 50-75 · strong 75-100 · heavy 100+ Oral duration: onset 0.5-1h · come-up 1-2h · peak 4-6h · offset 12-24h · total 17.5-33h · after-effects 24-72h Sublingual duration: onset 15-30m · come-up 0.75-1.5h · peak 3-5h · offset 12-24h · total 16-31h · after-effects 24-72h Transdermal duration: peak 4-6h · offset 12-24h · total 24-48h · after-effects 24-72h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 37.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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