Flubromazolam Stats - Substance Search

Interaction Warnings

⚠ dissociatives

This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.

⚠ stimulants

It is dangerous to combine benzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects.

Receptor Profile

Receptor Actions

Modulators

GABA-A receptor positive allosteric modulator (benzodiazepine site)

History & Culture

Flubromazolam, also designated JYI-73, is a novel synthetic triazolobenzodiazepine that emerged as part of the broader wave of designer benzodiazepines appearing on recreational drug markets. The substance first came to the attention of drug monitoring agencies following seizures by customs and law enforcement in Sweden, with the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) subsequently noting indications of its wider use as a recreational drug. Among designer benzodiazepines, flubromazolam has attracted particular concern from researchers and public health officials due to its exceptional potency, being active in the microgram range with an unusually prolonged duration of action. This pharmacological profile, combined with documented cases of life-threatening adverse reactions at doses as low as 3 milligrams, has led to warnings that flubromazolam and certain other potent triazolobenzodiazepines may pose substantially greater risks than many other substances in the designer benzodiazepine category.

Subjective Effects

Physical

The physical effects of flubromazolam can be broken down into several components which progressively intensify proportional to dosage.

Sedation: In terms of energy level alterations, this drug is extremely sedating and often results in an overwhelmingly lethargic state. At higher levels, this causes users to suddenly feel as if they are extremely sleep deprived and have not slept for days, forcing them to sit down and generally feel as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.
Motor control loss
Respiratory depression
Dizziness
Muscle relaxation

Cognitive

The cognitive effects of flubromazolam can be broken down into several components which progressively intensify proportional to dosage. The general head space of flubromazolam is described by many as one of intense sedation and decreased inhibition. It contains a large number of typical depressant cognitive effects.

Amnesia
Anxiety suppression
Thought deceleration
Disinhibition
Information processing suppression
Euphoria
Compulsive redosing
Delusions of sobriety: This is the false belief that one is perfectly sober despite obvious evidence to the contrary such as severe cognitive impairment and an inability to fully communicate with others.

Forked from Subjective Effect Documentation by Josie Kins, August 2015. Via dose.wiki (CC0).

Toxicity

PsychonautWiki

Flubromazolam likely has a low toxicity relative to dose. However, it is potentially lethal when mixed with depressants like alcohol or opioids. It is strongly recommended that one use harm reduction practices when using this substance.

Overdose

Benzodiazepine overdose may occur when a benzodiazepine is taken in extremely heavy quantities or concurrently with other depressants. This is particularly dangerous with other GABAergic depressants such as barbiturates and alcohol since they work in a similar fashion, but bind to distinct allosteric sites on the GABAA receptor. Thus, their effects potentiate one another.

Effect Profile

Curated + 5 Reports

Benzodiazepine 6.3

Strong anxiolysis with strong cognitive impairment, mild sedation, low euphoria

Anxiolysis×3

10

Sedation / Relaxation×2

5

Motor / Cognitive Impairment×1

8

Euphoria / Mood Lift×1

2

Based on reports from:

Erowid Experience Reports PsychonautWiki Flubromazolam

Tolerance & Pharmacokinetics

drugs.wiki

No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.

Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder

Cross-Tolerances

Alprazolam

Diazepam

Clonazepam

Lorazepam

Etizolam

Bromazolam

Clonazolam

Flualprazolam

Experience Report Analysis

Erowid

13 Reports

5 Single-substance

2015–2024 Date Range

12 With Age Data

Demographics

Gender Distribution

Too few reports for a chart: gender is known from 13 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

Male 13 of 13

Age Distribution

Reports Over Time

Real-World Dose Distribution

Erowid

From 9 of 12 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

Oral (n=7)

Median: 0.25mg 25th: 0.25mg 75th: 0.5mg 90th: 0.6mg

Common Combinations

Most co-occurring substances, as a share of all 13 reports filed under Flubromazolam

Too few reports for bars: these combinations come from 13 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

Clonazolam 4 of 13
Alcohol 3 of 13

Form / Preparation

Most common forms and preparations, as a share of the 8 reports that give one

Too few reports for bars: these forms come from 8 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

Liquid 4 of 8
Pill / Tablet 2 of 8
Powder / Crystals 2 of 8

Redose Patterns

Redosing behavior across 11 reports

0 of 11 Redosed

1.0 Avg Doses

Too few reports for a chart: redosing is known from 11 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

Single dose 11 of 11
Redosed 0 of 11

Benzodiazepine Equivalence

0.25 mg Flubromazolam = 10.0 mg Diazepam

Potency ratio 40.0

Flubromazolam - 0.25mg ~=10mg Diazepam.

⚠ All other CNS depressants.

Legal Status

Country	Status	Notes
Canada	Schedule IV	All benzodiazepines are controlled under Schedule IV of the Controlled Drugs and Substances Act.
Germany	NpSG (Neue-psychoaktive-Stoffe-Gesetz)	Controlled under the New Psychoactive Substances Act since July 18, 2019. Production and import with intent to distribute, administration to another person, and trading are punishable offenses. Possession is technically illegal but not subject to criminal penalties.
Netherlands	List 2 (Opiumwet)	Controlled under List 2 of the Opium Law (Opiumwet), making possession, distribution, and production illegal.
Poland	NPS controlled	Classified as a New Psychoactive Substance (NPS) under Polish drug legislation, making both possession and distribution illegal.
Russia	Schedule III	Listed as a Schedule III controlled substance since 2017 under Russian narcotics legislation.
Switzerland	Verzeichnis E	Specifically named as a controlled substance under Verzeichnis E of the Swiss Narcotics Act (Betäubungsmittelgesetz).
Turkey	Illegal	Classified as a controlled drug under Turkish law. Possession, production, supply, and import are all prohibited.
United Kingdom	Class C	Designated as a Class C controlled substance under the Misuse of Drugs Act 1971 as of May 31, 2017. Possession, production, and supply carry criminal penalties.
United States	Schedule I	Placed into Schedule I of the Controlled Substances Act as of January 23, 2023, indicating classification as having high abuse potential with no currently accepted medical use.

Flubromazolam Stats & Data