Mirogabalin
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 22 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 22 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Tarlige, Ds-5565, Mirogabalin besylate, Mirogabalin monobenzenesulfonate
Summary
Mirogabalin is approved in Japan and several Asian countries for diabetic peripheral neuropathic pain and postherpetic neuralgia. It has higher binding affinity and slower dissociation from Ξ±2Ξ΄-1 subunits compared to pregabalin, potentially offering improved analgesic effects with fewer CNS side effects. Dose adjustments are necessary for renal impairment: 50% reduction for moderate impairment (CrCl 30-60 mL/min) and 75% reduction for severe impairment.
Dose Information
Dose basis. Ranges synthesized from clinical dosing in trials and class comparisons; non-medical use carries added risk. Start at the lowest end, especially if combining with other sedatives or if renal function is reduced. User reports are sparse; avoid redosing within 12 hours to limit cumulative sedation. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-30mg (5-10 mg BID) | 30-40mg | 40-50mg+ |
Sources· 1 of 1 ladders not fully identified
Oral
Dose ladder — Light: Drugs.Wiki · Common: not identified · Strong, Heavy: Drugs.WikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 2-4 hrs | 3-6 hrs | 6.5-13 hrs |
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance builds with regular use over days to weeks, as with other gabapentinoids; waits of 1β3 weeks after cessation typically reduce tolerance significantly. Crossβtolerance within the class is expected but not complete; data are classβbased and partly anecdotal.
Cross-Tolerances
Effects
Effect glossary — · full glossary
Combinations
Cross-Check Mirogabalin with another substanceTrip Reports
Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Mirogabalin there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Mirogabalin Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 5-10 Β· common 10-30 (5-10 BID) Β· strong 30-40 Β· heavy 40-50+ Oral duration: onset 0.5-1h Β· come-up 1-2h Β· peak 2-4h Β· offset 3-6h Β· total 6.5-13h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 20 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
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